Chapter 12 Summary

The topics covered in this chapter can be summarized as follows:

• There are different types of chromosome maps: genetic (recombination), cytogenetic (metaphase chromosome), and physical maps.
• Recombination frequency is usually proportional to the distance between loci, and so recombination frequencies can be used to create genetic maps.
• Chromosomes can be distinguished cytologically based on their length, centromere position, and banding patterns when stained with dyes.
• Single clones can be restriction mapped and then combined into a contig that represents a larger region of DNA, ultimately the whole chromosome.
• The ultimate physical map is the DNA sequence of the whole chromosome or genome.